Uganda project aligns with three of the four TIBA focus areas.
• Improve diagnosis and surveillance of the pathogen T.b. rhodesiense in animals and people within the resource poor setting of central Uganda.
• The project will evaluate the stability and persistence of T.b. rhodesiense and assess the influence of a curative treatment.
• The project will determine the burden of infection in cattle that determines spill-over into humans, an event that marks the establishment of an active focus.
• This study will also permit evaluation of the level of under-reporting of rHAT making a direct comparison between clinical, parasitological and PCR methods.
• Deployment of existing drug treatments will be aligned to offer the maximum benefit to the local community. This will improve the management of infection, benefitting both the local human population and their livestock.
• Recommendations for interventions will be based upon the stability or persistence of infection in cattle and evidence of spill-over within the local human population. Persistent high-levels of T.b. rhodesiense infection in the animal reservoir will require a programme of continuous screening and deployment of chemoprophylaxis if rHAT is to be eliminated as a public health problem by 2030.